Melanotan research peptides are designed to mimic the natural hormone α-melanocyte-stimulating hormone (α-MSH), which helps stimulate melanocytes to produce eumelanin, leading to skin darkening and protection against UV radiation.
Melanotan peptides can help scientists, researchers, and medical professionals explore skin pigmentation, sunless tanning, photoprotection, and medicinal applications of melanogenesis.
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Melanotan 1 and Melanotan 2, both synthetic analogs of the alpha-melanocyte-stimulating hormone (α-MSH), are used primarily for their skin pigmentation effects. However, they differ in their molecular structure, effects, and potential applications.
Melanotan 1 (also known as Afamelanotide; Melanotan I; MT-1; or MT-I) is a synthetic analog of the alpha-melanocyte-stimulating hormone (α-MSH), which plays a key role in the pigmentation of skin. Initially developed to aid in the prevention of skin cancer by inducing tanning without exposure to harmful UV rays, Melanotan 1 mimics the body’s natural tanning process. It binds to melanocortin receptors, stimulating the production of melanin in the skin, which results in a deeper skin tone. Due to its potential to promote skin pigmentation, it has garnered interest not only in medical fields but also for cosmetic purposes. However, it is critical to note that the use of Melanotan 1 should be under strict medical supervision, and it is subject to regulatory approvals in various markets.
Buy Melanotan 1 Peptide Vial today! (Available as a single 10mg vial and also a kit which includes bateriostatic water and syringes)
Melanotan 1 functions by mimicking the effects of the natural hormone alpha-melanocyte-stimulating hormone (α-MSH). When administered, it binds to melanocortin receptors, specifically the MC1R receptor found in melanocytes, which are the cells responsible for producing melanin in the skin. This binding action stimulates these melanocytes to produce more melanin, the pigment responsible for skin, hair, and eye color. As melanin levels increase, skin pigmentation darkens, providing a protective barrier against UV radiation. This process results in a tanning effect without the need for prolonged sun exposure, thereby reducing the risk of skin damage and potential skin cancer development. The effectiveness and duration of the tanning effect can vary based on individual skin types and the dosage administered.
Molecular Formula: C78H111N21O19
Molecular Weight: 1646.8 g/mol
Sequence: Ac-Ser-Tyr-Ser-Nle-Glu-His-D-Phe-Arg-Trp-Gly-Lys-Pro-Val-NH2
Source: PubChem
Access our Melanotan 1 High-Performance Liquid Chromatography (HPLC) Certificate here.
Melanotan 2, also known as Melanotan II; MT-2; or MT-II, is another synthetic analog of the alpha-melanocyte-stimulating hormone (α-MSH). Similar to Melanotan 1, it promotes increased melanin production in the skin, thereby enhancing pigmentation and mimicking the natural tanning process. In addition to its tanning effects, Melanotan 2 has been studied for its potential to influence sexual function, appetite regulation, and energy homeostasis, making it a compound of interest in various research fields. Despite its potential benefits, Melanotan 2 also carries risks and side effects that necessitate cautious use under medical guidance. Regulatory approval and legal status of Melanotan 2 vary across different countries, hence it is essential for users to be aware of the legal implications in their respective regions.
Buy Melanotan 2 10mg Peptide Vial today! (Buy 10mg vial or a kit that contains bacteriostatic water and syringes for reconstituting.)
Melanotan 2 operates by mimicking the natural alpha-melanocyte-stimulating hormone (α-MSH) in the body. When introduced, it binds to melanocortin receptors, primarily MC1R found in melanocytes, which are responsible for melanin production. This interaction stimulates increased melanin synthesis, resulting in enhanced skin pigmentation. Beyond its effects on tanning, Melanotan 2 also influences other melanocortin receptors, including MC4R, which have roles in regulating sexual function, appetite, and energy balance. Consequently, users may experience additional physiological effects such as libido changes or appetite suppression. Given its broad range of actions and potential side effects, the administration of Melanotan 2 should be carefully managed and monitored by healthcare professionals. It is important to adhere to regulatory guidelines and consider the legal status of Melanotan 2 in the respective region before use.
Molecular Formula: C50H69N15O9
Molecular Weight: 1024.2 g/mol
Sequence: Ac-Nle-Asp(1)-His-D-Phe-Arg-Trp-Lys(1)-NH2
Source: PubChem
View the Melanotan 2 High-Performance Liquid Chromatography (HPLC) Certificate here.
Melanotan 1 Peptides
Buy Melanotan 1 nasal spray (MT-1) for clinical research from Spain Direct Sarms, available in 15ml and 30ml bottles.
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Melanotan 2 Peptides
Buy Melanotan II nasal sprays (MT-2) Peptides for research from Direct Sarms Spain.
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Are Melanotan peptides legal?
The legal status of Melanotan peptides varies by country. In the United States, neither Melanotan I nor Melanotan II is approved by the Food and Drug Administration (FDA) for medical or cosmetic use. As a result, their sale and distribution are considered illegal for personal use. In the United Kingdom, Melanotan peptides are not licensed for use either. The Medicines and Healthcare products Regulatory Agency (MHRA) has not approved them, and their marketing and sale are therefore prohibited. It is important to understand that these peptides are for research purposes only.
Are Melanotan peptides safe to use?
Research suggests potential benefits of Melanotan peptides, but their safety is still being evaluated. They can cause side effects like nausea, flushing, and changes in libido, requiring caution. Researchers should conduct in-depth studies to fully understand the risks and mechanisms involved. Any use should be under medical supervision, and it’s crucial to follow local regulations for safety and compliance.
How are Melanotan peptides administered?
Melanotan peptides are usually given through subcutaneous injections or nasal sprays, with the dosage and frequency varying by peptide and desired tan effect. Nasal sprays can be a more comfortable alternative to injections, possibly increasing user compliance. However, their effectiveness and absorption rates may not match those of injections, and more research is needed for optimization. Medical professionals should manage administration in clinical settings to ensure correct dosing and watch for side effects.
Can Melanotan peptides be used for weight management?
Research suggests that Melanotan 2 may influence appetite suppression and energy balance, offering potential benefits for weight management and obesity treatment. However, these effects require further validation through comprehensive clinical studies.
What potential side effects should researchers be aware of?
Common side effects associated with Melanotan peptides include nausea, flushing, increased libido, and appetite changes. More severe side effects can occur, especially with Melanotan 2, owing to its broader receptor activity. Given the potential for these adverse effects, it is critical for researchers to ensure comprehensive consultation with healthcare professionals prior to any application or study involving these compounds.
For more information, explore our latest blog posts dedicated to Melanotan peptides.
Direct Sarms Spain offers an extensive range of high-quality Melanotan peptides for sale, available in multiple formats to accommodate the diverse needs of researchers. Our selection includes peptide vials (available in 10mg vials and also kits with bacteriostatic water and syringes), nasal sprays 15ml and 30ml, and pre-mixed pens, offering versatile options for purchase.
[1] R.T.Dorr, G.Ertl and N.Levine (2004) Effects of a Superpotent Melanotropic Peptide in Combination With Solar UV Radiation on Tanning of the Skin in Human Volunteers – Jama Dermatology, 2004;140(7):827-835.
[2] L.M.Fitzgerald, J.L.Fryer, T.Dwyer, and S.M.Humphrey (2006) Effect of MELANOTAN, [Nle(4), D-Phe(7)]-alpha-MSH, on melanin synthesis in humans with MC1R variant alleles – Peptides, Volume 27, Issue 2, February 2006, Pages 388-394.
[3] H.Wessells, K.Fuciarelli, J.Hansen et al (1998) Synthetic melanotropic peptide initiates erections in men with psychogenic erectile dysfunction: double-blind, placebo controlled crossover study – Journal of Urology, 1998 Aug;160(2):389-93.
[4] H.Wessells, V.J.Hruby, J.Hackett et al (2006) MT-II Induces Penile Erection via Brain and Spinal Mechanisms – Annals of the New York Academy of Sciences, Volume 994, Issue 1, The Melanocortin System, June 2003, Pages 90-95.
[5] J.Ji An, Y.Rhee, S.H.Kim et al (2007) Peripheral effect of alpha-melanocyte-stimulating hormone on fatty acid oxidation in skeletal muscle – The Journal of Biological Chemistry, 2007 Feb 2;282(5):2862-70.
[6] Wessells, K.Fuciarelli, and J.Hansen (1998) Synthetic melanotropic peptide initiates erections in men with psychogenic erectile dysfunction: Double-blind placebo controlled crossover study – International Journal of Impotence Research volume 10, page263 (1998).
[7] C.Laustrup Møller, K.Raun et al (2011) Characterization of murine melanocortin receptors mediating adipocyte lipolysis and examination of signalling pathways involved – Molecular and Cellular Endocrinology, 2011 Jul 20;341(1-2):9-17.
[8] M.Navarro, F.Carvajal, J.M.Lerma-Cabrera et al (2015) Evidence that Melanocortin Receptor Agonist Melanotan-II Synergistically Augments the Ability of Naltrexone to Blunt Binge-Like Ethanol Intake in Male C57BL/6J Mice – Alcoholism, Clinical and Experimental Research, 2015 Aug;39(8):1425-33.
[9] D.A.York, S.Boghossian, M.Park-York (2011) Melanocortin activity in the amygdala influences alcohol intake – Pharmacology, Biochemistry and Behaviour, 2011 Mar;98(1):112-9.
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